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SemaglutidePopular

Weight Loss

Semaglutide

Medical weight management

4.8(56 verified reviews)
$349/mo
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This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.

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About Semaglutide

GLP-1 receptor agonist clinically proven for significant weight management results.

How it works

Semaglutide is a GLP-1 receptor agonist that mimics the body's natural incretin hormone. It slows gastric emptying, reduces appetite at the hypothalamic level, and improves insulin sensitivity. Clinical trials show 15-20% body weight loss over 68 weeks.

Clinical evidence

The landmark STEP 1 trial (Wilding et al., NEJM 2021) randomized 1,961 adults with obesity to weekly subcutaneous semaglutide 2.4 mg vs placebo. After 68 weeks, the semaglutide arm achieved a mean weight loss of 14.9% of body weight compared to 2.4% on placebo. The SUSTAIN program demonstrated significant HbA1c reduction in type 2 diabetes, and the SELECT trial (2023) extended the evidence to cardiovascular outcomes — semaglutide reduced major adverse cardiovascular events by 20% in overweight or obese adults with established cardiovascular disease. Compounded semaglutide uses the identical active pharmaceutical ingredient prepared by FDA-registered 503A pharmacies.

Benefits

Appetite control
Significant weight loss
Blood sugar support
Cardiovascular health

Semaglutide vs. Ozempic / Wegovy

Ozempic / Wegovy
$1349
per month at brand-name pricing
[pepti] Semaglutide
$349
Same active ingredient, ~75% less

Same active ingredient. Compounded at an FDA-registered 503A pharmacy.

Dosing

Your prescribing physician determines the right dose, schedule, and how it's administered — based on your goals, medical history, and lab work. Your personalized protocol is provided after your consultation.

Important safety information

+

Possible side effects

• Nausea (most common, especially first 2 weeks)
• Constipation or diarrhea
• Fatigue
• Heartburn
• Reduced appetite (this is the goal)

Do not use if you have

• Active cancer or history of cancer (unless approved by oncologist)
• Pregnancy or breastfeeding
• Severe kidney or liver disease
• Known allergy to the peptide or excipients
• Personal or family history of medullary thyroid cancer
• Multiple Endocrine Neoplasia syndrome type 2
• Pancreatitis history

If you experience severe side effects, call 911 or go to your nearest emergency room.

Frequently asked about Semaglutide

It's the same active ingredient. Ozempic (FDA-approved for diabetes) and Wegovy (FDA-approved for weight loss) are the brand-name versions. Compounded semaglutide is the same molecule, prepared by an FDA-registered 503A compounding pharmacy at significantly lower cost.

References

  1. Wilding JPH, Batterham RL, Calanna S, et al.. Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1) · New England Journal of Medicine (2021) · PMID 33567185
  2. Lincoff AM, Brown-Frandsen K, Colhoun HM, et al.. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT) · New England Journal of Medicine (2023) · PMID 37952131
  3. Wadden TA, Bailey TS, Billings LK, et al.. Effect of subcutaneous semaglutide vs placebo as an adjunct to intensive behavioral therapy on body weight in adults with overweight or obesity (STEP 3) · JAMA (2021) · PMID 33625476
  4. Rubino D, Abrahamsson N, Davies M, et al.. Weight regain and cardiometabolic effects after withdrawal of semaglutide (STEP 4) · JAMA (2021) · PMID 33755728

Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.

Read more about Semaglutide

News
Navigating the Regulatory Landscape of Compounded Peptides in 2026
Guides
How to Discuss Semaglutide with Your Doctor: A Guide
Guides
Myths About Wegovy®: Separating Fact from Fiction

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The assessment process available on the [pepti] website asks a series of medical questions, and the answers provided are reviewed by an independent licensed physician affiliated with our partner physician network. The licensed providers have established exclusionary criteria, and the answers provided determine if the individual is screened out of eligibility for treatment. The licensed clinicians retain the sole decision to prescribe peptide therapy and other compounded medications to patients. Treatment may be denied at the physician's sole discretion. If a prescription is not approved, you will not be charged for the medication.

Pharmacy Providers. [pepti] is a technology platform and is not a healthcare provider, pharmacy, or prescriber. All medications offered through the platform are compounded by independent FDA-registered 503A or 503B compounding pharmacies based on a valid prescription written by a licensed physician for an individual patient. Compounded medications are not FDA-approved as products. The active pharmaceutical ingredients used by our partner pharmacies are sourced from FDA-registered facilities. Compounded medications may not undergo the same testing or quality control as commercially manufactured FDA-approved drugs.

Results vary. Results from peptide therapy and other compounded treatments vary based on individual factors, including age, weight, medical history, adherence to the prescribed protocol, lifestyle factors, and physiological response. [pepti] makes no guarantee of any specific outcome. Statements about peptide therapy and compounded medications offered through the platform have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Product images. Product photographs and renderings shown on this website are for illustrative purposes only. The appearance of vials, packaging, labeling, and other materials you receive may vary and is determined by the dispensing compounding pharmacy.

Off-label use.Many peptides offered through the platform are prescribed for off-label use. “Off-label” means the medication is being prescribed for a use, dose, or patient population that is not specifically approved by the FDA. Off-label prescribing is legal and common in U.S. medical practice when supported by clinical experience and judgment.

Mailing & shipping. All orders ship in plain unmarked packaging via expedited delivery from our partner compounding pharmacies. Temperature-sensitive medications ship with insulated packaging and ice packs. Shipping is included at no additional cost in 45 U.S. states. We do not currently ship internationally or to APO/FPO addresses.

Not for emergencies. [pepti] is not designed for medical emergencies. If you are experiencing a medical emergency, call 911 or go to your nearest emergency room immediately. For urgent but non-emergency medical questions, contact your primary care provider or use an urgent care service.

No doctor-patient relationship with [pepti]. Your use of the platform does not create a doctor-patient relationship between you and pepti LLC. A doctor-patient relationship is established only between you and the independent licensed physician who reviews your intake and prescribes your treatment. The physicians who use the platform are independent contractors and are solely responsible for the medical care they provide.

Prescription medications. All prescription products require a valid prescription from a licensed healthcare provider. By using the platform, you acknowledge that you are at least 18 years old and that the information you provide is true, accurate, current, and complete. Providing false information may result in inappropriate treatment recommendations or denial of service.

Cosmetic & wellness products.Certain products offered through [pepti] — including skincare, hair care, body care, supplements, men's grooming, sports recovery, and sexual wellness products — are cosmetic or dietary supplement products, not prescription medications. These products do not require a prescription and are not reviewed or prescribed by a physician. Statements regarding dietary supplements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Results vary by individual. Consult your healthcare provider before starting any new supplement or topical product, especially if you are pregnant, nursing, or taking other medications.

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