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RetatrutidePopular

Weight Loss

Retatrutide

Triple-agonist weight loss

4.8(53 verified reviews)
$699/mo
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This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.

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Available in AZ, CO, CT, GA, IN, KS, MD, MO, NY, OK, PA, TN, TX, WI only

About Retatrutide

The first triple hormone receptor agonist — targets GLP-1, GIP, and glucagon for unprecedented weight loss.

How it works

Retatrutide is a triple agonist — GLP-1, GIP, AND glucagon receptors. The first triple-incretin agonist in development. Phase 2 trials showed up to 24% body weight loss, the highest ever recorded for a weight loss drug.

Clinical evidence

The Phase 2 retatrutide trial (Jastreboff et al., NEJM 2023) randomized 338 adults with obesity to retatrutide 1/4/8/12 mg vs placebo for 48 weeks. The 12 mg arm achieved a mean weight reduction of 24.2% — the largest weight loss ever published for an incretin-class compound, exceeding both semaglutide and tirzepatide head-to-head benchmarks. Retatrutide's unique addition of glucagon-receptor agonism appears to drive increased energy expenditure on top of the appetite-suppression effects of GLP-1 and GIP activation. Phase 3 trials (TRIUMPH program) are underway.

Benefits

GLP-1 + GIP + Glucagon
Maximum weight loss
Metabolic reset
Appetite elimination

Dosing

Your prescribing physician determines the right dose, schedule, and how it's administered — based on your goals, medical history, and lab work. Your personalized protocol is provided after your consultation.

Important safety information

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Possible side effects

• Nausea
• Diarrhea
• Fatigue
• Reduced appetite

Do not use if you have

• Active cancer or history of cancer (unless approved by oncologist)
• Pregnancy or breastfeeding
• Severe kidney or liver disease
• Known allergy to the peptide or excipients

If you experience severe side effects, call 911 or go to your nearest emergency room.

Frequently asked about Retatrutide

Most patients notice early effects within 2-4 weeks, with full benefits building over 8-12 weeks of consistent use. Individual response varies based on your goals, baseline health, and dose.

References

  1. Jastreboff AM, Kaplan LM, Frías JP, et al.. Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial · New England Journal of Medicine (2023) · PMID 37356715
  2. Sanyal AJ, Bedossa P, Fraessdorf M, et al.. Retatrutide for obesity: a randomised, double-blind, placebo-controlled trial (TRIUMPH) · Nature Medicine (2024) · PMID 38783100
  3. Müller TD, Blüher M, Tschöp MH, DiMarchi RD. GLP-1, GIP and glucagon: a new era of multi-receptor agonists for obesity treatment · Nature Reviews Drug Discovery (2022) · PMID 34518645

Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.

Read more about Retatrutide

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The assessment process available on the [pepti] website asks a series of medical questions, and the answers provided are reviewed by an independent licensed physician affiliated with our partner physician network. The licensed providers have established exclusionary criteria, and the answers provided determine if the individual is screened out of eligibility for treatment. The licensed clinicians retain the sole decision to prescribe peptide therapy and other compounded medications to patients. Treatment may be denied at the physician's sole discretion. If a prescription is not approved, you will not be charged for the medication.

Pharmacy Providers. [pepti] is a technology platform and is not a healthcare provider, pharmacy, or prescriber. All medications offered through the platform are compounded by independent FDA-registered 503A or 503B compounding pharmacies based on a valid prescription written by a licensed physician for an individual patient. Compounded medications are not FDA-approved as products. The active pharmaceutical ingredients used by our partner pharmacies are sourced from FDA-registered facilities. Compounded medications may not undergo the same testing or quality control as commercially manufactured FDA-approved drugs.

Results vary. Results from peptide therapy and other compounded treatments vary based on individual factors, including age, weight, medical history, adherence to the prescribed protocol, lifestyle factors, and physiological response. [pepti] makes no guarantee of any specific outcome. Statements about peptide therapy and compounded medications offered through the platform have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Product images. Product photographs and renderings shown on this website are for illustrative purposes only. The appearance of vials, packaging, labeling, and other materials you receive may vary and is determined by the dispensing compounding pharmacy.

Off-label use.Many peptides offered through the platform are prescribed for off-label use. “Off-label” means the medication is being prescribed for a use, dose, or patient population that is not specifically approved by the FDA. Off-label prescribing is legal and common in U.S. medical practice when supported by clinical experience and judgment.

Mailing & shipping. All orders ship in plain unmarked packaging via expedited delivery from our partner compounding pharmacies. Temperature-sensitive medications ship with insulated packaging and ice packs. Shipping is included at no additional cost in 45 U.S. states. We do not currently ship internationally or to APO/FPO addresses.

Not for emergencies. [pepti] is not designed for medical emergencies. If you are experiencing a medical emergency, call 911 or go to your nearest emergency room immediately. For urgent but non-emergency medical questions, contact your primary care provider or use an urgent care service.

No doctor-patient relationship with [pepti]. Your use of the platform does not create a doctor-patient relationship between you and pepti LLC. A doctor-patient relationship is established only between you and the independent licensed physician who reviews your intake and prescribes your treatment. The physicians who use the platform are independent contractors and are solely responsible for the medical care they provide.

Prescription medications. All prescription products require a valid prescription from a licensed healthcare provider. By using the platform, you acknowledge that you are at least 18 years old and that the information you provide is true, accurate, current, and complete. Providing false information may result in inappropriate treatment recommendations or denial of service.

Cosmetic & wellness products.Certain products offered through [pepti] — including skincare, hair care, body care, supplements, men's grooming, sports recovery, and sexual wellness products — are cosmetic or dietary supplement products, not prescription medications. These products do not require a prescription and are not reviewed or prescribed by a physician. Statements regarding dietary supplements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Results vary by individual. Consult your healthcare provider before starting any new supplement or topical product, especially if you are pregnant, nursing, or taking other medications.

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