Anti-Aging
Ipamorelin
Clean GH release
This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.
About Ipamorelin
The cleanest growth hormone secretagogue — stimulates GH without raising cortisol or prolactin.
How it works
Ipamorelin is a pentapeptide that selectively stimulates growth hormone release through the ghrelin receptor — without affecting cortisol, prolactin, or appetite. The cleanest GH secretagogue available.
Clinical evidence
Ipamorelin was characterized by Raun et al. (Eur J Endocrinol 1998) as the first ghrelin-mimetic with high selectivity for GH release without raising ACTH, cortisol, or prolactin — a profile that distinguishes it from other secretagogues like GHRP-2 and GHRP-6. Human studies have demonstrated dose-dependent GH elevation with minimal endocrine side effects. Clinical use in adults focuses on physiological GH/IGF-1 restoration to support body composition, recovery, and sleep architecture, often stacked with the GHRH analog CJC-1295 to extend the duration of GH pulses.
Benefits
Dosing
Your prescribing physician determines the right dose, schedule, and how it's administered — based on your goals, medical history, and lab work. Your personalized protocol is provided after your consultation.
Important safety information
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Possible side effects
Do not use if you have
If you experience severe side effects, call 911 or go to your nearest emergency room.
Frequently asked about Ipamorelin
Most patients notice early effects within 2-4 weeks, with full benefits building over 8-12 weeks of consistent use. Individual response varies based on your goals, baseline health, and dose.
References
- Raun K, Hansen BS, Johansen NL, et al.. Ipamorelin, the first selective growth hormone secretagogue · European Journal of Endocrinology (1998) · PMID 9849822
- Smith RG, Sun Y, Betancourt L, Asnicar M. Growth hormone secretagogues: physiological role and clinical utility · Trends in Endocrinology and Metabolism (2004) · PMID 15186871
- Andersen NB, Malmlöf K, Johansen PB, et al.. Effects of ipamorelin on body weight and food intake in 16-month-old female rats · Growth Hormone & IGF Research (2001) · PMID 11437502
Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.
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