Skin & Hair
GHK-Cu (Injectable)
Systemic skin & collagen repair
This treatment requires licensed provider review and approval. Treatment is not guaranteed. If prescribed, medication is fulfilled by a licensed U.S. pharmacy where permitted by law. Compounded medications are not FDA-approved or FDA-cleared.
About GHK-Cu (Injectable)
Copper peptide GHK-Cu stimulates collagen synthesis, skin remodeling, and hair follicle health.
How it works
GHK-Cu is a copper peptide that stimulates collagen I and III, elastin, decorin, and glycosaminoglycans. It promotes hair follicle growth, accelerates wound healing, and drives skin remodeling at the dermal level.
Clinical evidence
GHK-Cu is one of the most-studied peptides in dermatology, with over 100 published papers since Pickart's foundational work in the 1970s. Documented effects include collagen synthesis upregulation (Maquart et al., FEBS Lett 1988), accelerated wound healing in diabetic mice (Pickart, Brief Funct Genomics 2017), and gene expression changes consistent with skin regeneration. Pickart & Margolina's 2018 Cosmetics review reported clinical trials showing improvements in skin firmness, elasticity, fine lines, and wound healing. Mechanistically GHK-Cu also modulates antioxidant defenses (SOD, glutathione) and reduces inflammatory cytokines. The peptide is a small ligand that releases copper into cells in a controlled manner, supporting both the structural collagen scaffold and the antioxidant defense system simultaneously.
Benefits
Dosing
Your prescribing physician determines the right dose, schedule, and how it's administered — based on your goals, medical history, and lab work. Your personalized protocol is provided after your consultation.
Important safety information
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Possible side effects
Do not use if you have
If you experience severe side effects, call 911 or go to your nearest emergency room.
Frequently asked about GHK-Cu (Injectable)
Most patients notice early effects within 2-4 weeks, with full benefits building over 8-12 weeks of consistent use. Individual response varies based on your goals, baseline health, and dose.
References
- Maquart FX, Pickart L, Laurent M, et al.. Stimulation of collagen synthesis in cultured fibroblasts by GHK-Cu · FEBS Letters (1988) · PMID 3169225
- Pickart L, Margolina A. GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration · BioMed Research International (2015) · PMID 26236730
- Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data · International Journal of Molecular Sciences (2018) · PMID 29986520
- Pickart L. The human tri-peptide GHK and tissue remodeling · Journal of Biomaterials Science, Polymer Edition (2008) · PMID 18554493
Citations are provided for educational purposes. They do not constitute medical advice. Always discuss any peptide protocol with your prescribing physician.
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